Related Experiment Video
Updated: Jul 18, 2026
Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper
Published on: January 19, 2024
Ganglioglioma: comparison with other low-grade brain tumors
Paulo Thadeu Brainer-Lima1, Alessandra Mertens Brainer-Lima, Hildo Rocha Azevedo-Filho
1Division of Neurosurgery, Hospital da Restauração, University of Pernambuco, Recife PE, Brazil. brainerlima@uol.com.br
Method:
Forty-two patients with low-grade brain tumor and refractory epilepsy were studied. The mean age was 22.3 years. They were divided into two groups: Group A, patients with ganglioglioma (n=19) and group B, patients with other low-grade tumors (n=23) (14 astrocytoma, 6 oligodendroglioma, 2 dysembryoplastic neuroepithelial tumor, and 1 xanthoastrocytoma).
Results:
Age at seizures onset was 7 years or less in 73% of the patients in group A and in 30.4% of the patients in group B (p=0.045). Complex partial occurred frequently in group A and B (94.7% versus 82%, respectively). Seizures frequency was higher in group B (p=0.002). Computerized tomography (CT) was normal in 36.8% of group A patients and abnormal in all group B patients. Magnetic resonance imaging (MRI) was abnormal in all patients. Surgical removal was complete in 89.5% of the patients in group A and in 78.2% of the patients in group B.
Conclusion:
The association of refractory epilepsy and complex partial seizures, at a relatively low frequency, in young patients potentially normal CT and a MRI hypointense temporal lobe lesion in T1-weighed slices were habitual image findings in ganglioglioma, rather than other low-grade tumor.
