Search research articles

Search research articles

Related Experiment Videos

Immunological tolerance and autoimmunity.

Sergio Romagnani¹

¹Department of Internal Medicine, Excellence Centre Denothe, University of Florence, Florence, Italy. s.romagnani@dmi.unifi.it

Internal and Emergency Medicine

|November 24, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Human TH1 and TH2 Subsets.

International archives of allergy and immunology·2021

Same author

Cell-mediated and humoral adaptive immune responses to SARS-CoV-2 are lower in asymptomatic than symptomatic COVID-19 patients.

European journal of immunology·2020

Same author

The COVID-19 infection: lessons from the Italian experience.

Journal of public health policy·2020

Same author

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent.

The Journal of clinical investigation·2020

Same author

Eomes controls the development of Th17-derived (non-classic) Th1 cells during chronic inflammation.

European journal of immunology·2018

Same author

The Kinetics of Antidrug Antibodies, Drug Levels, and Clinical Outcomes in Infliximab-Exposed Patients with Immune-Mediated Disorders.

The journal of allergy and clinical immunology. In practice·2018

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Immunological tolerance prevents self-attack by immune cells. Breakdown of this tolerance, influenced by genetics and infections, can lead to autoimmune diseases.

Area of Science:

Immunology
Autoimmunity

Background:

Immunological tolerance prevents immune responses against self-antigens.
Central and peripheral mechanisms maintain tolerance.
T regulatory cells are crucial for suppressing self-reactive immune responses.

Purpose of the Study:

To explain the mechanisms of immunological tolerance.
To discuss the role of T regulatory cells.
To explore factors contributing to the breakdown of tolerance and autoimmunity.

Main Methods:

Review of central and peripheral tolerance mechanisms.
Discussion of T regulatory cell function.
Analysis of genetic and environmental factors in autoimmunity.

Main Results:

Related Experiment Videos

Central tolerance eliminates self-reactive lymphocytes in primary lymphoid organs.
Peripheral tolerance involves anergy, deletion, or suppression of mature lymphocytes.
Infections can trigger autoimmunity through inflammation or molecular mimicry.

Conclusions:

Maintaining immunological tolerance is vital for preventing autoimmunity.
Both genetic predisposition and environmental factors, particularly infections, contribute to autoimmune disease development.