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Updated: Jul 18, 2026

A Unified Methodological Framework for Vestibular Schwannoma Research

A Unified Methodological Framework for Vestibular Schwannoma Research

Published on: June 20, 2017

Linear accelerator radiosurgery for vestibular schwannomas.

William A Friedman¹, Patrick Bradshaw, Adam Myers

¹Department of Neurosurgery, University of Florida, Gainesville, Florida 32610, USA. friedman@neurosurgery.ufl.edu

Journal of Neurosurgery

|November 24, 2006

Summary

Linear accelerator (LINAC) radiosurgery is a safe and effective treatment for small vestibular schwannomas (VSs). This study shows high tumor control rates and low complication risks, offering a viable alternative to surgery.

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Area of Science:

Neurosurgery
Radiation Oncology
Otolaryngology

Background:

Vestibular schwannomas (VSs) are tumors affecting the nerve connecting the ear to the brain.
Radiosurgery using linear accelerators (LINAC) has emerged as a primary treatment modality for small VSs.
Evaluating long-term outcomes of LINAC radiosurgery for VSs is crucial for treatment planning.

Purpose of the Study:

To review a large, single-institution experience with LINAC radiosurgery for VSs.
To analyze local tumor control rates and complication incidence.
To identify factors influencing treatment outcomes.

Main Methods:

A retrospective review of 390 patients with VSs treated between 1988 and 2005.
Prospective data collection on patient and treatment variables.

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Last Updated: Jul 18, 2026

A Unified Methodological Framework for Vestibular Schwannoma Research

A Unified Methodological Framework for Vestibular Schwannoma Research

Published on: June 20, 2017

Actuarial and multivariate statistical analyses of tumor control and complication rates (facial/trigeminal neuropathy).

Main Results:

High actuarial tumor control rates: 98% at 1-2 years and 90% at 5 years.
Low complication rates: 4.4% facial weakness, 3.6% facial numbness.
Reduced complication rates observed after lowering radiation doses to 1250 cGy since 1994.

Conclusions:

LINAC radiosurgery is a safe and effective treatment option for small VSs.
Tumor control is high, with a low risk of significant complications.
Radiosurgery represents a valuable alternative to surgical intervention for select VS patients.