Related Experiment Video
Updated: Jul 18, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Preparation of prolonged release clarithromycin microparticles for oral use and their in vitro evaluation
Lüffi Genç1, Müzeyyen Demirel, Yasemin Yazan
1Department of Pharmaceutical Technology, Anadolu University, Faculty of Pharmacy, 26470, Eskisehir Turkiye. lgenc@anadolu.edu.tr
Abstract:
Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, particle size distribution, X-ray diffraction, thermal behavior, active agent content and in vitro dissolution from the microparticles were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. All the formulations obtained showed prolonged release when compared to pure clarithromycin. Microparticles prepared by spray-drying method had a slower release compared to those of casting-drying method. Spray-drying method seems to be a more suitable method to prepare microparticles for prolongation in release.
Related Concept Videos
Modified-Release Drug Delivery Systems: Bioavailability
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
In Vitro Drug Dissolution: Compendial Testing Models I
In Vitro Drug Dissolution: Alternative Methods
Oral Drug Delivery Systems: Delayed-Release Systems
In Vitro Drug Release Testing: Overview, Development and Validation
