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A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
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Clinical effect of a triclosan containing dentifrice on gingivitis during pregnancy and post-partum

Petcharat Kraivaphan1, Cholticha Amornchat, Terdphong Triratana

  • 1Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|November 24, 2006
PubMed

One hundred forty pregnant women 3 months gestation were enrolled in a 9 month, double-blind clinical study to evaluate the effect of 0.3% triclosan/copolymer dentifrice on gingivitis, compared to a placebo dentifrice. Women were stratified into two balanced groups according to their baseline gingivitis scores. They then received oral prophylaxis and were assigned to use either a placebo or the triclosan dentifrice for the next 9 months. The 3, 5 and 9 month results of this study showed that the triclosan dentifrice provided statistically significant reductions in gingivitis of 19.73, 27.91and 38.45%, respectively, compared to the placebo dentifrice.

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