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Cutaneous plasmacytomas with amyloid in six dogs
P H Rowland1, B A Valentine, K E Stebbins
1Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca.
Veterinary Pathology
|March 1, 1991
Summary
This study diagnosed cutaneous plasmacytomas with amyloid deposition in older dogs. Neoplastic plasma cells produced immunoglobulin G, suggesting a primary amyloid origin in these canine tumors.
Area of Science:
- Veterinary Pathology
- Oncology
- Immunology
Background:
- Cutaneous plasmacytomas are rare canine neoplasms.
- Amyloid deposition can occur secondary to various conditions, but primary amyloidosis of immunoglobulin origin is less common in dogs.
Purpose of the Study:
- To characterize cutaneous plasmacytomas with associated amyloid deposition in dogs.
- To investigate the origin of the amyloid material in these canine tumors.
Main Methods:
- Diagnosis of six canine cutaneous plasmacytomas using light microscopy.
- Immunofluorescent staining for anti-canine immunoglobulins to identify monoclonal plasma cell populations.
- Polarized light microscopy and Congo red staining after potassium permanganate treatment to assess amyloid characteristics.
Main Results:
- Six older dogs (mean age 10.7 years) were diagnosed with cutaneous plasmacytomas and amyloid deposition.
- Neoplastic plasma cells exhibited plasmacytoid features with variable pleomorphism.
- Immunofluorescence confirmed a monoclonal plasma cell population (IgG) in four tumors.
- Amyloid deposits were consistent with immunoglobulin origin, showing birefringence after potassium permanganate treatment.
Conclusions:
- Cutaneous plasmacytomas in dogs can be associated with local amyloid deposition.
- The amyloid material is likely of immunoglobulin (IgG) origin, indicating primary amyloidosis.
- Further research is warranted to understand the pathogenesis and clinical implications of these canine neoplasms.