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Related Experiment Videos

Case report: dextran-induced acute anuric renal failure.

B R Kurnik1, F Singer, W C Groh

  • 1Department of Medicine, UMDNJ/Robert Wood Johnson Medical School, Camden.

The American Journal of the Medical Sciences
|July 1, 1991
PubMed
Summary

Acute renal failure from dextran-40 is rare but possible, especially with radiocontrast. Plasmapheresis may offer therapeutic benefits for this adverse reaction.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Toxicology

Background:

  • Dextran-40 is a plasma volume expander.
  • Radiocontrast agents are used in medical imaging.
  • Acute renal failure (ARF) is a potential complication of medical treatments.

Observation:

  • A case of anuric acute renal failure is presented.
  • The patient was a 59-year-old female.
  • The renal failure occurred after administration of dextran-40 and radiocontrast.

Findings:

  • Dextran-40 can infrequently cause acute renal failure.
  • Concomitant use of radiocontrast may increase the risk of ARF.
  • Radiocontrast-induced ischemia is implicated in the pathogenesis.

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Implications:

  • Healthcare providers should be aware of the risk of ARF with dextran-40, particularly when combined with radiocontrast.
  • Understanding the pathogenesis involving ischemia is crucial for prevention and treatment.
  • Plasmapheresis shows potential as a therapeutic intervention for dextran-40-induced ARF.