Related Experiment Video
Updated: Jul 18, 2026
Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure
Published on: August 27, 2019
[Spontaneous discharge modulation by acetylcholine in chronically compressed rat dorsal root ganglion neurons]
1Department of Neurology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China. sjnkyhj@163.com
Objective:
To study the effects of acetylcholine (ACh) on spontaneous discharges of compressed rat dorsal root ganglion (DRG) neurons.
Methods:
In chronically compressed DRG model, the spontaneous discharge of a single fiber from the DRG neuron in response to ACh treatment was recorded.
Results:
Active spontaneous discharges were recorded in the injured DRG, and 77.9% of the injured DRG neurons responded to Ach treatment in the manner of simple excitation, or excitation followed by inhibition. The responses were enhanced with the increase of Ach concentration.
Conclusion:
Injured DRG remains active in spontaneous discharges, which can be significantly influenced by ACh treatment.
