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Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
[Radioprotective effect of catechines against radiation injury in mice]
Wei-min Shi1, Xin-ping Zhao, Ting Lu
1Department of Oncology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China.
Objective:
To study the radioprotective effect of catechines against radiation injury in mice.
Methods:
Catechines were administered in mice intragastrically at the daily dose of 200 mg/kg for 10 consecutive days before whole body irradiation with 6 Gy X-rays. The body weight changes, survival time, 30-day survival rate, and counts of peripheral white blood cells were recorded.
Results:
The mice with catechine pre-treatment before X-ray exposure suffered less body weight loss than those without the treatment before exposure. Catechines markedly increased the survival time of the irradiated mice, and raised the 30-d survival rate of the irradiated mice to 53.33% as compared with the rate of 13.33% in the radiated mice without catechine pre-treatment. Catechines significantly promoted recovery of peripheral white blood cells.
Conclusion:
Catechines have definite radioprotective effect against radiation injury in mice.
