Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction.
Heung-Woo Park1, Eun-Soon Shin, Jong-Eun Lee
1Department of Internal Medicine, Seoul National University, 28 Yongondong, Chongno-gu, Seoul 110-744, Republic of Korea.
Thorax
|November 24, 2006
Summary
Gene-gene interactions between vascular endothelial growth factor receptor 2 (KDR) and tumor necrosis factor-alpha (TNF) significantly influence atopy risk in Korean children. Specific variants in KDR and TNF increase the likelihood of developing atopy.
Area of Science:
- Genetics
- Immunology
- Environmental Health
Background:
- Atopy is a complex genetic trait influenced by gene-gene interactions.
- Understanding these interactions is crucial for complex genetic diseases.
Purpose of the Study:
- To investigate gene-gene interactions in the development of atopy.
- To identify specific genetic factors contributing to atopy risk.
Main Methods:
- Analysis of 2055 Korean children and adolescents (10-18 years).
- Atopy defined by positive skin prick tests to common inhalant allergens.
- Gene-gene interactions among 12 polymorphic loci in seven candidate genes analyzed using multidimensionality-reduction method.
Main Results:
- Significant interaction found between KDR (V297I) and TNF (-308G-->A) variants in atopy development.
- Individuals with variant alleles in both KDR and TNF showed a 2.23-fold increased risk of atopy.
- Cross-validation consistency was 10/10 with a prediction error of 35.9% (p=0.001).
Conclusions:
- KDR and TNF gene variants synergistically contribute to atopy development.
- Gene-gene interactions play a significant role in the etiology of atopy in Korean youth.
