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Acoustic techniques for assessing the Optison destruction threshold.

Tyrone M Porter1, Denise A B Smith, Christy K Holland

  • 1Department of Biomedical Engineering, University of Cincinnati, OH, USA. tmp@bu.edu

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|November 24, 2006
PubMed
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This study determined the pressure threshold for Optison (octafluoropropane contrast agent) destruction using ultrasound. The identified threshold for acoustically driven diffusion was 0.15 MPa, with destruction rates increasing with pressure.

Area of Science:

  • Ultrasound physics
  • Biomedical acoustics
  • Medical imaging

Background:

  • Ultrasound contrast agents like Optison enhance diagnostic imaging.
  • Understanding the destruction mechanisms of these agents is crucial for safety and efficacy.
  • Acoustically driven diffusion is a key factor in microbubble behavior under ultrasound.

Purpose of the Study:

  • To determine the pressure threshold for Optison destruction.
  • To utilize both laboratory and clinical ultrasound systems for this investigation.
  • To quantify the relationship between ultrasound pressure and Optison microbubble stability.

Main Methods:

  • A laboratory-assembled 3.5-MHz pulsed ultrasound system and a clinical diagnostic scanner were used.
  • Optison suspensions were insonated with varying peak rarefactional pressures (Pr).

Related Experiment Videos

  • Scattering intensity was quantified to determine decay constants and identify the destruction threshold.

    • Main Results:

    • The pressure threshold for Optison destruction via acoustically driven diffusion was found to be 0.15 MPa (Mechanical Index=0.08).
    • Decay constants from radio frequency data and B-mode images showed good agreement.
    • Increased ultrasound exposure pressure led to a higher rate of Optison destruction.

    Conclusions:

    • Optison destruction can be quantified using both laboratory and clinical ultrasound systems.
    • The pressure threshold for acoustically driven diffusion was successfully identified.
    • Three distinct mechanisms of ultrasound contrast agent destruction were observed using acoustic techniques.