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Published on: October 23, 2018

PI3K, RSK, and mTOR signal networks for the GST gene regulation

Sang Geon Kim1, Seung Jin Lee

  • 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, South Korea. sgk@snu.ac.kr

Toxicological Sciences : an Official Journal of the Society of Toxicology
|November 24, 2006
PubMed

Insights

Glutathione S-transferases (GST) induction aids cell survival and cancer prevention. This review details molecular mechanisms, focusing on transcription factors and signaling pathways like PI3K-Akt/ERK-RSK1-mTOR.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Glutathione S-transferases (GST) are crucial for cellular detoxification and survival.
  • GST induction plays a role in cancer prevention.
  • Gene expression is regulated by transcription factors via transcriptional or posttranscriptional mechanisms.

Purpose of the Study:

  • To summarize the molecular mechanisms underlying the transcriptional induction of the GST gene.
  • To explore the role of transcription factors and co-regulators in GST gene expression.
  • To differentiate signaling pathways involved in GST induction by various agents.

Main Methods:

  • Review of existing literature on GST gene regulation.
  • Analysis of molecular mechanisms involving transcription factors.
  • Examination of cell signaling pathways, including PI3K-Akt/ERK-RSK1-mTOR.

Main Results:

  • GST induction is linked to cytoprotective agents activating PI3K-Akt/ERK-RSK1-mTOR pathways.
  • Transcription factors coordinate GST gene expression.
  • Mechanisms for GST induction may differ between cytoprotective agents and prooxidants/toxicants.

Conclusions:

  • Transcriptional induction of GST involves a series of transcription factors.
  • These factors recruit coactivators or corepressors to regulate gene expression.
  • Understanding these mechanisms is key for cancer prevention and therapeutic strategies.

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