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Related Experiment Video

Updated: Jul 18, 2026

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

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Published on: October 6, 2014

Microcarcinoids in large intestinal adenomas.

Melissa Pulitzer¹, Ruliang Xu, Arief A Suriawinata

¹Department of Pathology, Division of Gastrointestinal Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA.

The American Journal of Surgical Pathology

|November 24, 2006

Summary

Colonic adenomas with microcarcinoids are rare, benign lesions. These findings suggest microcarcinoids may be precursors to composite adenoma-carcinoid tumors, with a favorable patient prognosis.

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Area of Science:

Gastroenterology
Surgical Pathology
Endocrinology

Background:

Composite adenoma-carcinoid tumors are rare mixed endocrine-glandular neoplasms of the colon.
Unlike other mixed neoplasms, their glandular component is benign with a favorable natural history.

Observation:

Four cases of colonic adenomas containing hitherto undescribed microcarcinoids were identified.
Microcarcinoids measured 0.5-1.5 mm, located in the basal lamina propria, interposing between crypts and muscularis mucosae.
Histologically, microcarcinoids showed nests/cords of low-grade cells with endocrine markers (Grimelius, chromogranin, synaptophysin, NSE, somatostatin) but no mitotic activity or p53/MIB-1 positivity.

Findings:

The glandular component was benign in 3 cases; one showed mixed adenomatous-endocrine differentiation.
Patients experienced a benign clinical course with a median follow-up of 2 years.
Hemicolectomy in two patients with incomplete polypectomies revealed no residual endocrine neoplasia.

Implications:

Colonic adenomas with microcarcinoids represent a potential precursor to composite adenoma-carcinoid tumors or a related entity.
Awareness of microcarcinoids is crucial to avoid diagnostic pitfalls due to their pleomorphism and basal location.
Further clarification of their natural history and relationship to composite tumors is warranted.