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Related Experiment Video

Updated: Jul 18, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

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Acute chorea associated with metoclopramide use.

Jordan S Dubow¹, Jerrold Leikin, Michael Rezak

¹Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

American Journal of Therapeutics

|November 24, 2006

Summary

Metoclopramide, a dopamine antagonist, can cause movement disorders. This case report details a patient who developed choreiform movements after metoclopramide administration, highlighting a rare side effect.

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Area of Science:

Neurology
Pharmacology

Background:

Metoclopramide is a dopamine antagonist used for gastrointestinal and nausea symptoms.
It is known to cause extrapyramidal side effects, excluding chorea.

Observation:

A patient developed choreiform movements after intravenous metoclopramide.
Other causes for chorea were ruled out during the work-up.

Findings:

The patient's choreiform movements resolved with quetiapine and diazepam treatment.
This suggests metoclopramide may induce chorea, a previously undocumented side effect.

Implications:

This case expands the known side effect profile of metoclopramide.
Clinicians should consider chorea in patients presenting with movement disorders after metoclopramide use.