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Published on: November 8, 2011
CD56-positive large B-cell lymphoma
James Weisberger1, Wojciech Gorczyca, Marsha C Kinney
1Bio-REFERENCE Laboratories, Inc, Elmwood Park, NJ 07407, USA. jweisberger@bioreference.com
Applied Immunohistochemistry & Molecular Morphology : AIMM
|November 24, 2006
Summary
CD56 B-cell lymphomas are rare, identified in less than 0.5% of cases. This study explores their unique characteristics, suggesting they may represent a distinct subtype of large B-cell lymphoma.
Area of Science:
- Immunology
- Hematology
- Oncology
Background:
- CD56 (NCAM) is a neural adhesion molecule typically found on natural killer cells and T-cell subsets.
- CD56 expression is common in plasma cell myeloma and acute myelogenous leukemia, but rare in B-cell lymphoma.
Purpose of the Study:
- To identify and characterize CD56-expressing B-cell lymphomas.
- To explore the potential relationship of CD56 expression to B-cell differentiation and clinical presentation.
Main Methods:
- Flow cytometry was used to identify CD56 B-cell lymphomas.
- Immunophenotypic analysis including CD10 and BCL6 expression was performed.
- Clinical data including disease presentation was reviewed.
Main Results:
- A cohort of 20 CD56 B-cell lymphomas was identified between 2001-2003 (<0.5% of B-cell lymphomas).
- Most cases (90%) expressed CD10, and 5/5 tested cases expressed BCL6, suggesting a follicular lymphoma origin.
- Extranodal disease presentation occurred in 45% of cases.
Conclusions:
- CD56 B-cell lymphomas may represent a novel subset of large B-cell lymphoma.
- The expression of CD56 in B-cell lymphomas is associated with specific immunophenotypic markers and extranodal presentation.
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