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Related Experiment Videos

CD56-positive large B-cell lymphoma.

James Weisberger1, Wojciech Gorczyca, Marsha C Kinney

  • 1Bio-REFERENCE Laboratories, Inc, Elmwood Park, NJ 07407, USA. jweisberger@bioreference.com

Applied Immunohistochemistry & Molecular Morphology : AIMM
|November 24, 2006
PubMed
Summary
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CD56 B-cell lymphomas are rare, identified in less than 0.5% of cases. This study explores their unique characteristics, suggesting they may represent a distinct subtype of large B-cell lymphoma.

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • CD56 (NCAM) is a neural adhesion molecule typically found on natural killer cells and T-cell subsets.
  • CD56 expression is common in plasma cell myeloma and acute myelogenous leukemia, but rare in B-cell lymphoma.

Purpose of the Study:

  • To identify and characterize CD56-expressing B-cell lymphomas.
  • To explore the potential relationship of CD56 expression to B-cell differentiation and clinical presentation.

Main Methods:

  • Flow cytometry was used to identify CD56 B-cell lymphomas.
  • Immunophenotypic analysis including CD10 and BCL6 expression was performed.
  • Clinical data including disease presentation was reviewed.

Main Results:

Related Experiment Videos

  • A cohort of 20 CD56 B-cell lymphomas was identified between 2001-2003 (<0.5% of B-cell lymphomas).
  • Most cases (90%) expressed CD10, and 5/5 tested cases expressed BCL6, suggesting a follicular lymphoma origin.
  • Extranodal disease presentation occurred in 45% of cases.

Conclusions:

  • CD56 B-cell lymphomas may represent a novel subset of large B-cell lymphoma.
  • The expression of CD56 in B-cell lymphomas is associated with specific immunophenotypic markers and extranodal presentation.