Related Experiment Video
Updated: Jul 18, 2026
07:55
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
[Soft tissue carcinoma. Epidemiology, diagnostics and therapy]
H Rechl1, K Wörtler, G Weirich
1Klinik für Orthopädie und Sportorthopädie, Klinikum rechts der Isar, Technische Universität, Ismaninger Strasse 22, 81675 München, Deutschland. h.rechl@lrz.tum.de
Der Orthopade
|November 24, 2006
Summary
Treatment for soft tissue sarcoma is multimodal and tailored. Surgery combined with radiotherapy improves survival rates for intermediate-grade tumors, but high-grade sarcomas often metastasize.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Context:
- Soft tissue sarcomas are a heterogeneous group of tumors requiring individualized treatment strategies.
- Treatment decisions depend on tumor grade, size, and clinical presentation.
- Multimodal therapy is often necessary for optimal patient outcomes.
Purpose:
- To outline current therapeutic approaches for soft tissue sarcoma based on tumor characteristics.
- To highlight the role of surgery and radiotherapy in managing localized and recurrent disease.
- To emphasize the importance of tailored treatment plans for improving survival and local control.
Summary:
- Resection is standard for small, low-grade superficial tumors.
- For intermediate-grade tumors, resection with negative margins plus radiotherapy achieves nearly 80% survival.
- High-grade sarcomas (>5 cm) managed with resection and radiotherapy have a 50% metastasis rate; local recurrence warrants re-resection, with radiotherapy efficacy linked to tumor burden.
Impact:
- Informs clinical decision-making for soft tissue sarcoma management.
- Emphasizes the prognostic significance of tumor grade and size.
- Highlights the critical role of achieving negative resection margins and optimizing radiotherapy delivery.
Related Concept Videos
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...