Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Spermatogenesis01:22

Spermatogenesis

Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of Enfortumab Vedotin-Associated Diabetic Ketoacidosis With Severe Insulin Resistance in a Nondiabetic Woman.

JCEM case reports·2024
Same author

Characterization of a chromatin-associated TCF7L1 complex in human embryonic stem cells.

Proteomics·2024
Same author

The impact of transition to a digital hospital on medication errors (TIME study).

NPJ digital medicine·2023
Same author

Geroscience Approaches to Women's Health in an Aging World.

The journals of gerontology. Series A, Biological sciences and medical sciences·2021
Same author

Toilet Paper, Minced Meat and Diabetes Medicines: Australian Panic Buying Induced by COVID-19.

International journal of environmental research and public health·2021
Same author

IMAGING REDOX STATE HETEROGENEITY WITHIN INDIVIDUAL EMBRYONIC STEM CELL COLONIES.

Journal of innovative optical health sciences·2021

Related Experiment Video

Updated: Jul 18, 2026

Isolation and Derivation of Mouse Embryonic Germinal Cells
14:01

Isolation and Derivation of Mouse Embryonic Germinal Cells

Published on: October 22, 2009

Embryonic germ cells: when germ cells become stem cells.

Candace L Kerr1, John D Gearhart, Aaron M Elliott

  • 1Institute for Cell Engineering, Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, Maryland 21205, USA.

Seminars in Reproductive Medicine
|November 24, 2006
PubMed
Summary

Embryonic germ cells (EGCs), derived from primordial germ cells (PGCs), are pluripotent stem cells capable of self-renewal and differentiation. These cells show potential for treating various human conditions, including diabetes and neurological disorders.

More Related Videos

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
12:06

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Published on: January 11, 2019

Differentiation of Newborn Mouse Skin Derived Stem Cells into Germ-like Cells In vitro
09:47

Differentiation of Newborn Mouse Skin Derived Stem Cells into Germ-like Cells In vitro

Published on: July 16, 2013

Related Experiment Videos

Last Updated: Jul 18, 2026

Isolation and Derivation of Mouse Embryonic Germinal Cells
14:01

Isolation and Derivation of Mouse Embryonic Germinal Cells

Published on: October 22, 2009

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
12:06

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Published on: January 11, 2019

Differentiation of Newborn Mouse Skin Derived Stem Cells into Germ-like Cells In vitro
09:47

Differentiation of Newborn Mouse Skin Derived Stem Cells into Germ-like Cells In vitro

Published on: July 16, 2013

Area of Science:

  • Stem Cell Biology
  • Developmental Biology
  • Reproductive Biology

Background:

  • Embryonic germ cells (EGCs) are pluripotent stem cells originating from primordial germ cells (PGCs).
  • PGCs are the precursors to gametes, diverging from somatic lineages during embryonic development.
  • EGCs have been successfully derived from multiple species, including mice, humans, chickens, and pigs.

Purpose of the Study:

  • To summarize the characteristics and potential applications of embryonic germ cells (EGCs).
  • To highlight the pluripotency, differentiation capabilities, and developmental potential of EGCs.
  • To underscore the therapeutic promise of EGCs for various human diseases.

Main Methods:

  • Derivation and culture of EGCs from PGCs.
  • In vitro differentiation assays to assess pluripotency (e.g., embryoid body formation).
  • In vivo studies including teratocarcinoma formation and chimeric animal generation.

Main Results:

  • EGCs exhibit long-term self-renewal and differentiate into all three germ layers.
  • In vivo transplantation of EGCs leads to teratocarcinomas and contributes to chimeric animals, including germline transmission.
  • EGCs maintain normal karyotypes and genomic imprinting patterns.

Conclusions:

  • EGCs are a valuable model for studying early development and pluripotency.
  • EGCs hold significant therapeutic potential for treating conditions like diabetes, and neurological and urological disorders.
  • Further transplantation studies are ongoing to define the clinical applications of EGCs.