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Related Experiment Videos

Embryo morphology and development are dependent on the chromosomal complement.

M Cristina Magli1, Luca Gianaroli, Anna Pia Ferraretti

  • 1Reproductive Medicine Unit, Società Italiana di Studi di Medicina della Riproduzione, Bologna, Italy.

Fertility and Sterility
|November 25, 2006
PubMed
Summary
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Beyond aneuploidy: embryo morphology, maternal age, and miscarriage dynamics in PGT-A selected single embryo transfer.

Journal of assisted reproduction and genetics·2025

Embryo fragmentation and abnormal cell division rates correlate with higher rates of chromosomal abnormalities (aneuploidy). This suggests that deviations in embryo development can indicate underlying genetic issues, impacting viability.

Area of Science:

  • Reproductive medicine
  • Genetics
  • Embryology

Background:

  • Preimplantation genetic diagnosis (PGD) for aneuploidy is crucial for patients with poor pregnancy prognosis.
  • Embryo morphology is often used as a non-invasive indicator of embryo quality and viability.

Purpose of the Study:

  • To investigate the relationship between embryo morphology and chromosomal status.
  • To assess the impact of aneuploidy on fragmentation, delayed cleavage, and arrested cleavage.

Main Methods:

  • Retrospective analysis of 916 preimplantation genetic diagnosis cycles.
  • Analysis of chromosomes XY, 13, 15, 16, 18, 21, and 22 in blastomeres from day 3 embryos.
  • Evaluation of embryo morphology, chromosomal status, and reanalysis of non-transferred embryos.

Related Experiment Videos

Main Results:

  • Higher incidence of chromosomal abnormalities in arrested, slow-cleaving, or fast-cleaving embryos compared to normally developing embryos.
  • Association between uneven blastomere numbers or perivitelline space fragments and increased chromosomal abnormalities.

Conclusions:

  • Embryo development patterns deviating from expected timelines and symmetry are linked to higher rates of chromosomal abnormalities.
  • Embryo fragmentation is related to chromosomal status, potentially affecting embryo viability.