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Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter telomeres than other...
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Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
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Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
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Functional Cloning Using a Xenopus Oocyte Expression System
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To clone alone: the United Nations' Human Cloning Declaration.

Rosario M Isasi1, George J Annas,

  • 1Research Centre for Public Law, University of Montreal, Canada.

Revista De Derecho Y Genoma Humano = Law and the Human Genome Review
|November 28, 2006
PubMed
Summary

Efforts to establish a global treaty on human cloning by the United Nations were unsuccessful. Instead, a non-binding Declaration on Human Cloning was adopted in 2005.

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Area of Science:

  • Bioethics
  • International Law
  • Biotechnology Governance

Background:

  • The United Nations (UN) engaged in a prolonged effort, spanning nearly four years, to develop a legally binding international treaty specifically addressing the complex issue of human cloning.
  • This initiative aimed to establish a unified global framework for regulating or prohibiting human cloning technologies.

Framework:

  • The comprehensive treaty negotiations ultimately failed to reach a consensus among member states.
  • In lieu of a treaty, the UN General Assembly adopted a non-binding Declaration on Human Cloning in 2005.

Implementation:

  • The Declaration serves as a political statement and a moral guide rather than an enforceable legal instrument.
  • Its adoption signifies a shift from regulatory treaty-making to a more flexible, non-binding approach to addressing emerging biotechnologies.

Implications:

  • The UN Declaration on Human Cloning reflects the challenges in achieving international consensus on sensitive bioethical issues.
  • It highlights the evolving landscape of global governance for advanced scientific and medical technologies, emphasizing ethical considerations and national sovereignty.