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Updated: Jul 18, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cytotoxic cis-fused bicyclic sesquiterpenoids from Jatropha neopauciflora
Abraham García1, Guillermo Delgado
1Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán 04510, México, DF.
Abstract:
Analysis of polar fractions of the bark extract of Jatropha neopauciflora provided two uncommon cis-fused bicyclic sesquiterpenoids, which were characterized as (1R,2R,5S,6S,7S,10S)*-5-epi-eudesm-4(15)-ene-1alpha,2beta,6alpha-triol (1) and (1R,2R,5S,6S,7R,10S)*-ax-4(15)-ene-1alpha,2beta,7beta-triol (2). Their absolute configuration and biogenesis were derived by correlations with congeners of known absolute configurations. Biological investigation of less polar fractions of the bark extract led to the isolation of moderately cytotoxic triterpenes, calenduladiol (3) and (3beta,16beta)-16-hydroxylup-20(29)-en-3-yl (E)-3-(4-hydroxyphenyl)prop-2-enoate (4).
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