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Acylphloroglucinol derivatives from Hypericum prolificum
Geneive E Henry1, Smita Raithore, Yanjun Zhang
1Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, Pennsylvania 17870, USA. henry@susqu.edu
Abstract:
Three new acylphloroglucinol derivatives have been isolated from the hexane extract of the aerial parts of Hypericum prolificum L.: prolificin A (1), prolifenone A (2), and prolifenone B (3). The structures were elucidated on the basis of extensive 2D NMR and MS data. All three compounds were evaluated for in vitro cell proliferation inhibitory activity against human breast (MCF-7), lung (NCI-H460), CNS (SF-268), stomach (AGS), and colon (HCT-116) tumor cell lines. Prolificin A showed growth inhibition of all cell lines with IC50 values ranging from 23 to 36 microM. Prolifenones A and B were inactive at the concentrations tested.
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