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Published on: April 2, 2017
Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A
V Moulisová1, M Srbová, O Jedlicková
1Department of Plant Physiology, Faculty of Biological Sciences, University of South Bohemia, Ceske Budejovice, 370 05, Czech Republic. vladimira.moulisova@email.cz
Abstract:
An effect of cyclosporin A on lipid peroxidation in isolated rat hepatocytes was tested. A significant increase in lipid peroxidation marker (the concentration of lipofuscin-like pigments) was observed in samples incubated with cyclosporin A in comparison with the control. When hepatoprotective flavonoid silybin was added, the production of lipofuscin-like pigments decreased significantly. This result indicates a potential positive role of silybin in lowering of cyclosporin A side effects associated with the production of reactive oxygen species and plasma membrane damage.