Related Experiment Video
Updated: Jul 18, 2026
Transurethral Instillation Procedure in Adult Male Mouse
Published on: November 2, 2017
An aqueous garlic extract alleviates water avoidance stress-induced degeneration of the urinary bladder
Beyhan Sağlam1, Esra Cikler, Ali Zeybek
1Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey.
Objective:
To investigate the role of aqueous garlic extract (AGE) on the water-avoidance stress (WAS)-induced degeneration of the urinary bladder in a rat model.
Materials And Methods:
Wistar albino rats were exposed to WAS for 2 h/day for 5 days (WAS group), after which, AGE (1 mL/kg) was injected intraperitoneally into the rats (WAS + AGE group). Urinary bladder samples were investigated with both light and scanning electron microscopy, and lipid peroxidation and glutathione levels were also measured in the samples.
Results:
In the WAS group there was inflammatory cell infiltration, more mast cells and ulcerated areas in the mucosa. In the WAS + AGE group there was relatively normal urothelial alignment, moderate inflammatory cell infiltration and fewer mast cells in the mucosa. The increased lipid peroxidation and decreased glutathione levels in WAS rats were reversed by AGE treatment.
Conclusions:
These results show that AGE has a protective effect on WAS-induced degenerative changes in the urinary bladder.
Related Concept Videos
01:23Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
01:28Microbiota of the Urogenital Tract