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[Proteus penneri].

Rafael Cantón1, M Paz Sánchez-Moreno, María Isabel Morosini Reilly

  • 1Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, España. rcanton.hrc@salud.madrid.org

Enfermedades Infecciosas Y Microbiologia Clinica
|November 28, 2006
PubMed
Summary

Proteus penneri, a nosocomial pathogen, is often misidentified and exhibits unique antibiotic resistance due to the HugA beta-lactamase. Understanding its resistance profile is crucial for effective clinical treatment.

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Area of Science:

  • Microbiology
  • Clinical Infectious Diseases
  • Bacterial Pathogenesis

Context:

  • Proteus penneri, previously P. vulgaris biogroup 1, is a distinct species identified in 1982.
  • This bacterium shares clinical similarities and pathogenic factors with Proteus mirabilis and Proteus vulgaris.
  • Predominantly isolated from nosocomial infections, particularly urine (50%), wound exudates (25%), and blood cultures (15%).

Purpose:

  • To highlight the diagnostic challenges in identifying Proteus penneri, especially its misidentification as P. vulgaris by automated systems lacking the indole test.
  • To characterize the unique antimicrobial susceptibility profile of P. penneri, focusing on the role of the HugA beta-lactamase.
  • To elucidate the genetic basis and phenotypic expression of HugA-mediated resistance.

Summary:

  • Proteus penneri is a nosocomial pathogen frequently isolated from urine and wound infections.
  • It can be misidentified as P. vulgaris due to reliance on automated systems that omit the indole test.
  • A key feature is the inducible beta-lactamase, HugA, conferring resistance to aminopenicillins and early-generation cephalosporins, with altered activity against later-generation agents.
  • HugA's activity is similar to extended-spectrum beta-lactamases (ESBLs) and is inhibited by clavulanic acid.

Impact:

  • Accurate identification of P. penneri is essential to avoid misdiagnosis and ensure appropriate antibiotic selection.
  • Understanding the HugA beta-lactamase mechanism aids in predicting resistance patterns and managing infections caused by this species.
  • The study emphasizes the need for specific diagnostic tests, like the indole test, for reliable Proteus species differentiation in clinical settings.

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