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Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview

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Related Experiment Video

Updated: Jul 18, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Emerging strategies for increasing high-density lipoprotein.

James S Forrester1, Prediman K Shah

  • 1Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA. forrester@cshs.org

The American Journal of Cardiology
|November 28, 2006
PubMed
Summary

New therapies show promise for increasing high-density lipoprotein cholesterol (HDL-C) and enhancing reverse cholesterol transport, potentially reducing coronary heart disease events.

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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

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Last Updated: Jul 18, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism

Background:

  • High-density lipoprotein cholesterol (HDL-C) is a key antiatherosclerotic agent.
  • HDL-C's mechanisms include cholesterol efflux, reduced oxidation, and inflammation inhibition.

Purpose of the Study:

  • To review potent methods for increasing HDL-C and enhancing reverse cholesterol transport.
  • To evaluate emerging therapies in clinical trials for cardiovascular risk reduction.

Main Methods:

  • Review of current literature on HDL-C and reverse cholesterol transport.
  • Examination of novel agents including CETP inhibitors, ApoA-I Milano, D4F, dual PPAR agonists, and rimonabant.

Main Results:

  • Lifestyle modifications yield modest HDL-C increases (5-15%).
  • Niacin provides greater increases (25-35%) at high doses.
  • Emerging therapies are in clinical trials for enhanced HDL-C and RCT.

Conclusions:

  • Novel agents hold potential to significantly reduce coronary disease incidence.
  • Combination therapies may offer synergistic benefits for cardiovascular event reduction.