Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

Drug Dosing: Infants and Children

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Unrecognized Academic Role of the Jewish Hospitals and Their Staff during the Nazi Era.

The Israel Medical Association journal : IMAJ·2026

Same author

Electric scooter related injuries among children: a single institutional experience.

BMC pediatrics·2025

Same author

The Nuremberg Racial Laws: The End of Jewish Medical Teaching in Germany. Who Were the Last Jewish Medical Professors in Berlin?

The Israel Medical Association journal : IMAJ·2024

Same author

Electronically Monitored Adherence to Short-Term Antibiotic Therapy in Children.

Pediatrics·2022

Same author

Persistent post-concussive syndrome in children after mild traumatic brain injury is prevalent and vastly underdiagnosed.

Scientific reports·2022

Same author

Pediatric Hospitalizations After School Reopening During the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Alpha (B.1.1.7) Variant Spread: A Multicenter Cross-sectional Study in Israel.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2022

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

Medication errors in children.

Eran Kozer¹, Matitiahu Berkovitch, Gideon Koren

¹Pediatric Emergency Services, Assaf Harofeh Medical Center, Zerifin 70300, Israel.

Pediatric Clinics of North America

|November 28, 2006

Summary

Medication errors, especially dosing mistakes, harm many children, particularly those in intensive care. Implementing systems like computerized order entry can significantly reduce these preventable patient safety incidents.

Area of Science:

Pediatric patient safety and medication administration.
Iatrogenic injury prevention in healthcare settings.

Background:

Medication errors represent a significant cause of iatrogenic injuries in pediatric populations.
Dosing errors are the predominant type of medication errors within pediatrics.
Critically ill children in intensive care units (ICUs) and emergency departments (EDs) face heightened risks from these errors.

Observation:

Sicker pediatric patients in critical care settings are disproportionately affected by medication dosing errors.
Specific interventions have demonstrated efficacy in mitigating medication errors.

Findings:

Computerized physician order entry (CPOE) systems.
Standardized preprinted order forms.
Color-coded medication systems.

More Related Videos

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Related Experiment Videos

Last Updated: Jul 18, 2026

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Implications:

Adopting a 'systems approach' is paramount for healthcare institutions aiming to improve patient safety.
System-level interventions are crucial for reducing medication errors and preventing pediatric harm.
Enhanced safety protocols are essential in high-risk pediatric environments like ICUs and EDs.