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The genetic background to PTSD.

B F P Broekman¹, M Olff, F Boer

¹Department of Psychiatry, Academic Medical Centre-De Meren, University of Amsterdam, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands.

Neuroscience and Biobehavioral Reviews

|November 28, 2006

Summary

Genetic research into posttraumatic stress disorder (PTSD) is limited. Studies on candidate genes show inconsistent results, suggesting complex gene-environment interactions influence PTSD vulnerability.

Area of Science:

Psychiatric Genetics
Neuroscience
Molecular Biology

Background:

Extensive research exists on the genetic underpinnings of psychiatric disorders.
However, polygenic influences in posttraumatic stress disorder (PTSD) remain poorly understood.

Purpose of the Study:

To review molecular genetic studies investigating the genetic basis of PTSD.
To identify key candidate genes and assess current understanding of their role in PTSD etiology.

Main Methods:

Literature search of Medline, Embase, and Web of Science databases.
Review of association studies examining major genotypes and candidate genes (e.g., serotonin, dopamine, glucocorticoid, BDNF).

Main Results:

Studies have investigated numerous candidate genes, including those in the serotonin, dopamine, glucocorticoid, GABA, apolipoprotein, BDNF, and NPY systems.

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Results from these association studies are largely inconsistent, potentially due to methodological limitations and low statistical power.

The complex nature of PTSD, requiring a traumatic event, complicates the identification of specific contributing genes.

Conclusions:

Current molecular genetic research on PTSD has yielded inconsistent findings.
Identifying specific genes contributing substantially to PTSD is challenging due to its complex etiology.
Future research should focus on gene-environmental interactions and studies with distinct endophenotypes and environmental factor assessments.