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Updated: Jul 18, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
BCL-2, TP53 and BAX protein expression in superficial urothelial bladder carcinoma
Ricardo Gonzalez-Campora1, Guillermo Davalos-Casanova, Antonio Beato-Moreno
1Department of Pathology, Virgen Macarena University Hospital and University of Seville Medical School, Seville, Spain. rcampora@us.es
Abstract:
Whether TP53, BCL-2 and BAX expressions add independent prognostic information in patients with Ta/T1 bladder urothelial carcinoma remains unclear. TP53 overexpression correlated with high tumor grade (p=0.004), WHO grading categories (0.045), BAX expression (p=0.043) and pathologic stage (p=0.05). BCL-2 immunostaining was inverse associated with tumor grade (p=0.008). Lack of BAX expression was related to reduced patient's survival (p=0.028). Mortality was higher in patients with BCL-2+/TP53+ (p=0.023) or TP53+/BAX- (p=0.027) phenotype. BAX and pathologic stage were independent predictors of progression-free and overall survival, respectively. Therefore, BAX expression might be relevant in patient's prognosis.
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