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T cell immune responses to HIV-1

Sandhya Vasan1, Sarah J Schlesinger, Geraldine Arrode

  • 1The Aaron Diamond AIDS Research Center, 455 First Avenue, 7th Floor, New York, New York 10016, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|November 28, 2006
PubMed

The recent use of multiparametric flow cytometry to monitor T cell immune responses complements traditional assays, such as IFN-gamma ELISPOT, to provide more information on the functional complexity of CD4+ and CD8+ T cell immune responses induced either by natural infection, or by immunization. In this review, we provide a general background on T cell subsets, and describe the cellular immune response during natural HIV-1 infection. We then review T cell responses to current candidate HIV-1 vaccines. Taken together, this helps to formulate our understanding of the immune correlates of protection required for an effective prophylactic HIV-1 vaccine. Finally, we emphasize current dendritic cell based vaccine strategies designed to modulate immunity to establish immune protection against HIV-1.

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