Related Experiment Video
Updated: Jul 18, 2026
06:53
In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
Published on: February 21, 2025
Yeast as a model system to study glucose-mediated signalling and response
1Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010-Valencia, Spain. sanz@ibv.csic.es
Frontiers in Bioscience : a Journal and Virtual Library
|November 28, 2006
Summary
Glucose acts like a hormone, regulating cell metabolism and gene expression. Studies in yeast (Saccharomyces cerevisiae) reveal molecular mechanisms of glucose signaling, aiding understanding in mammalian cells.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Glucose is a primary carbon and energy source for diverse cells.
- Glucose influences cellular metabolism, gene expression, and growth.
- Glucose signaling pathways adjust cellular functions based on availability.
Purpose of the Study:
- To review glucose-mediated signaling mechanisms in yeast (Saccharomyces cerevisiae).
- To discuss how yeast studies inform understanding of glucose signaling in mammalian cells.
Main Methods:
- Review of existing literature on glucose signaling pathways.
- Comparative analysis of glucose response mechanisms between yeast and mammalian cells.
Main Results:
- Yeast (Saccharomyces cerevisiae) shares conserved signal transduction components with eukaryotes for glucose detection and response.
- Mechanisms elucidated in yeast provide insights into fundamental cellular responses to glucose.
Conclusions:
- Yeast serves as a valuable model organism for studying glucose signaling.
- Understanding glucose response in yeast contributes to comprehending cellular metabolism and gene regulation in higher eukaryotes.
Related Concept Videos
01:28Yeast Signaling
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
01:02Glucose Homeostasis: Regulation of Blood Glucose
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
01:22Bioreactor Controls-III
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...