Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Gut Microbiota in Fish Viral Infection: Mechanisms and Microbiota-Targeted Interventions.

Aquaculture nutrition·2026
Same author

A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs.

Cell reports·2026
Same author

Mef2d regulates mutually exclusive expression of IgZ and IgM isotypes through epigenetic modulation in a zebrafish model.

Fundamental research·2026
Same author

Genome-wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target.

iMeta·2025
Same author

Novel DNJ Derivative Ameliorates Cardiac Hypertrophy by Targeting OPA1 and Restoring Mitochondrial Health.

Circulation research·2025
Same author

SVCV phosphoprotein hijacks phase separation to immobilize the IRF3-TBK1 signaling axis and suppress interferon antiviral immunity.

Journal of virology·2025

Related Experiment Video

Updated: Jul 18, 2026

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

Osteoclast differentiation and gene regulation.

Qingxiao Zhao1, Jianzhong Shao, Wei Chen

  • 1Life Science College, Zhejiang University, Hongzhou, China.

Frontiers in Bioscience : a Journal and Virtual Library
|November 28, 2006
PubMed
Summary

This review explores transcription factors and cytokines crucial for osteoclast differentiation and function. Understanding these molecular mechanisms is key to developing new therapies for bone diseases like osteoporosis.

More Related Videos

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Related Experiment Videos

Last Updated: Jul 18, 2026

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Area of Science:

  • Bone Biology and Cellular Mechanisms
  • Molecular Endocrinology
  • Skeletal Pathophysiology

Background:

  • Osteoclasts are critical for bone remodeling and implicated in diseases like osteoporosis and arthritis.
  • Osteoclast activity is regulated by specific gene expression patterns driven by transcription factors and cytokines.

Purpose of the Study:

  • To provide an updated review of key transcription factors and cytokines involved in osteoclast differentiation and function.
  • To highlight the role of these factors in various bone-related diseases and discuss relevant animal models.

Main Methods:

  • Literature review of scientific publications on osteoclast biology.
  • Analysis of studies focusing on transcription factors (e.g., PU.1, NF-kappaB, NFATc1) and cytokines (e.g., M-CSF, RANKL).
  • Examination of data from animal models illustrating the in vivo roles of these factors.

Main Results:

  • Identified critical transcription factors including PU.1, NF-kappaB, AP-1, NFATc1, Mitf, Myc, and Src.
  • Highlighted the importance of cytokines such as M-CSF and RANKL in osteoclastogenesis.
  • Summarized findings from animal models demonstrating the functional significance of these molecular players.

Conclusions:

  • Transcription factors and cytokines orchestrate osteoclast differentiation and function.
  • Further research into these pathways is essential for understanding osteoclast-related diseases.
  • This knowledge can guide the development of novel therapeutic interventions for skeletal disorders.