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Updated: Jul 18, 2026
13:41
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Vaccines against human papillomavirus
Yen-Yu Lin1, Hannah Alphs, Chien-Fu Hung
1Department of Pathology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, Maryland 21287, USA.
Frontiers in Bioscience : a Journal and Virtual Library
|November 28, 2006
Summary
Human papillomavirus (HPV) vaccines show promise for preventing and treating HPV-related cancers. Therapeutic vaccines target early viral antigens to combat existing infections and malignancies.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Human papillomavirus (HPV) is a key cause of cervical, anogenital, and some head and neck cancers.
- HPV vaccines offer potential for both prevention and treatment of HPV-associated malignancies.
Purpose of the Study:
- To explore the potential of prophylactic and therapeutic HPV vaccines in controlling and eradicating HPV infections and related cancers.
- To highlight the distinct targets of prophylactic (L1, L2 capsid proteins) and therapeutic (E6, E7 early antigens) HPV vaccines.
Main Methods:
- Prophylactic vaccines induce neutralizing antibodies against HPV L1 and L2 capsid proteins to prevent infection.
- Therapeutic vaccines target non-structural early viral antigens (E6, E7) to treat established infections and malignancies.
Main Results:
- Preclinical studies demonstrate the efficacy of HPV vaccines.
- Several HPV vaccine clinical trials are underway based on promising preclinical results.
Conclusions:
- Successful clinical outcomes could lead to the control and eventual eradication of oncogenic HPV infections.
- Vaccination represents a significant strategy for managing HPV-related cancers.
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