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Activation of the mitochondrial pathway of apoptosis by oxysterols

Gabriella Leonarduzzi1, Giuseppe Poli, Barbara Sottero

  • 1Department of Clinical and Biological Sciences of University of Turin, San Luigi Hospital, 10043 Orbassano, Turin, Italy.

Frontiers in Bioscience : a Journal and Virtual Library
|November 28, 2006
PubMed

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
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