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Related Concept Videos

Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
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Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
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Electron Transport Chain: Complex I and II

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Overview of Metabolism

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Related Experiment Video

Updated: Jul 18, 2026

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
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Mitochondrial ferritin in animals and plants.

Andrea Galatro1, Susana Puntarulo

  • 1Physical Chemistry-PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.

Frontiers in Bioscience : a Journal and Virtual Library
|November 28, 2006
PubMed
Summary

Mitochondrial ferritin (mtF) sequesters iron within mitochondria, unlike ubiquitous cytosolic ferritins. Understanding mtF

Area of Science:

  • Biochemistry
  • Cell Biology
  • Mitochondrial Biology

Background:

  • Ferritins store iron, preventing toxicity by sequestering Fe atoms.
  • Mitochondria generate reactive oxygen species and possess nitric oxide synthase activity.
  • Cytosolic ferritins are ubiquitous, but mitochondrial ferritin (mtF) expression is tissue-specific.

Purpose of the Study:

  • To investigate the role and function of mitochondrial ferritin (mtF).
  • To explore the metabolic interactions of mtF within mitochondria.
  • To understand mtF's potential role in iron homeostasis and oxidative metabolism.

Main Methods:

  • Comparative sequence analysis of mtF and cytosolic ferritins.
  • Analysis of mtF expression patterns in various tissues.

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Isolation and Respiratory Measurements of Mitochondria from Arabidopsis thaliana

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  • Investigation of Fe binding and oxidation properties of mtF.

    • Main Results:

    • Mitochondrial ferritin (mtF) exhibits distinct Fe binding and oxidation properties compared to cytosolic H-ferritin.
    • mtF expression is restricted to specific tissues like testis, neuronal cells, and islets of Langerhans, not major storage organs.
    • Evidence suggests mtF functions differently from cytosolic ferritin, potentially in iron homeostasis within mitochondria.

    Conclusions:

    • Mitochondrial ferritin plays a specialized role in iron metabolism within mitochondria.
    • Understanding mtF's function may offer insights into neurodegenerative disorders and iron-related diseases.
    • Further research into mtF's unique properties and functions is warranted.