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Activated protein C in sepsis and beyond: update 2006

Lisa J Toltl1, Lucy Y Y Shin, Patricia C Y Liaw

  • 1Department of Medical Sciences at McMaster University, and the Henderson Research Centre, Hamilton, Ontario, Canada.

Frontiers in Bioscience : a Journal and Virtual Library
|November 28, 2006
PubMed

Insights

Activated protein C (APC) is an anticoagulant that also acts as a signaling molecule. Research shows APC has therapeutic potential beyond sepsis, including in stroke and wound healing.

Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Background:

  • Activated protein C (APC) is a plasma serine protease primarily known for its anticoagulant properties.
  • APC degrades coagulation factors Va and VIIIa, inhibiting the coagulation cascade.
  • Recent research reveals APC as a signaling molecule linking coagulation, inflammation, apoptosis, and vascular permeability.

Purpose of the Study:

  • To review key studies on the diverse biological activities of APC.
  • To summarize the therapeutic potential of APC beyond its anticoagulant function.
  • To explore APC's role in conditions such as sepsis, stroke, and wound healing.

Main Methods:

  • Comprehensive literature review of PubMed up to May 2006.
  • Analysis of studies investigating APC's anticoagulant and signaling functions.
  • Synthesis of research on APC's therapeutic applications in various diseases.

Main Results:

  • APC exhibits multifaceted biological activities beyond anticoagulation.
  • APC modulates pathways involved in sepsis, inflammation, and cell death.
  • Evidence supports APC's therapeutic potential in stroke, ischemia-reperfusion injury, and wound healing.

Conclusions:

  • APC is a critical signaling molecule with broad therapeutic implications.
  • APC's protective effects in sepsis are linked to its ability to modulate multiple pathways.
  • Further research into APC's non-anticoagulant functions may unlock new treatment strategies.

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