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Updated: Jul 18, 2026

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Published on: May 18, 2021
Float on: lipid rafts in the lifecycle of HIV
Doris Wilflingseder1, Heribert Stoiber
1Department of Hygiene, Medical Microbiology and Social Medicine, Innsbruck Medical University, Fritz-Preglstr.3, 6020 Innsbruck, Austria. doris.wilflingseder@i-med.ac.at
Abstract:
All steps in the HIV lifecycle--entry, assembly, budding, induction of signal transduction and subsequent cell activation--are complex multifactorial mechanisms where cholesterol and sphingolipids (glycosphingolipids--GSLs and sphingomyelins in mammalian cells) are closely involved. Here we will review the contribution of these heterogeneous membrane lipid microdomains, referred to as lipid rafts, DIGs (detergent-insoluble glycolipid-enriched complexes), DRMs (detergent-resistant membranes), GEMs (glycolipid-enriched membranes), caveolae, TIMs (Triton-insoluble membranes) for interactions of HIV with the host cell. The accurate terminology was discussed elsewhere, and to simplify matters we will use rafts or lipid rafts throughout the review.
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