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Updated: Jul 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Three pathogenic determinants in immune nephritis--anti-glomerular antibody specificity, innate triggers and host
1Department of Internal Medicine (Rheumatology) and the Center for Immunology, University of Texas Southwestern Medical School, Dallas, TX 75235, USA.
Abstract:
The prevailing notion is that lupus nephritis is mediated by autoantibodies, particularly those that bind to DNA and/or glomeruli. However it has become apparent that the development of immune-mediated renal disease is contingent upon additional factors including innate stimuli and host genetics. The purpose of this review is to evaluate our current understanding of three factors that can potentially influence immune-mediated renal disease: (1) Anti-glomerular/DNA antibodies (Abs), (2) Innate triggers, including Toll-Like Receptor (TLR) stimulation, and (3) the genetic makeup of the host.
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