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Published on: May 31, 2017
Two new eremophilanolides from Xanthium sibiricum
Xiao-Qi Zhang1, Wen-Cai Ye, Ren-Wang Jiang
1Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, PR China.
Natural Product Research
|November 28, 2006
Summary
Two novel eremophilanolides, sibiriolides A and B, were discovered in Xanthium sibiricum. Their structures were elucidated using advanced spectroscopic and crystallographic methods.
Area of Science:
- Natural Product Chemistry
- Organic Chemistry
- Pharmacognosy
Background:
- Xanthium sibiricum is a plant species known for its diverse phytochemical constituents.
- Eremophilanolides are a class of sesquiterpenoids with potential biological activities.
Purpose of the Study:
- To isolate and characterize new chemical compounds from the aerial parts of Xanthium sibiricum.
- To determine the precise structures of the newly identified eremophilanolides.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation employing High-Resolution Electron Ionization Mass Spectrometry (HREIMS) and Nuclear Magnetic Resonance (NMR) spectroscopy.
- Confirmation of stereochemistry via X-ray crystallographic analysis and Circular Dichroism (CD) measurements.
Main Results:
- Two new eremophilanolides, designated sibiriolides A (1) and B (2), were successfully isolated.
- The detailed structures and stereochemical configurations of sibiriolides A and B were determined.
- Compound 1: 4S,5R,7R,8R,11R-2-oxo-1(10)-eremophilen-12,8-olide; Compound 2: 4S,5R,7R,8R,11S-2-oxo-1(10)-eremophilen-12,8-olide.
Conclusions:
- The study expands the known chemical diversity of eremophilanolides from Xanthium sibiricum.
- The identified compounds represent new molecular entities with potential for further investigation.
- The structural data provides a foundation for future research into the biological properties and synthetic pathways of these compounds.
