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Modafinil and cocaine interactions.

Robert Malcolm1, Karla Swayngim, Jennifer L Donovan

  • 1Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA. malcolmr@musc.edu

The American Journal of Drug and Alcohol Abuse
|November 28, 2006
PubMed
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Modafinil did not cause significant hemodynamic changes when combined with intravenous cocaine. This medication did reduce cocaine

Area of Science:

  • Pharmacology
  • Clinical Trials
  • Neuroscience

Background:

  • Cocaine dependence is a significant public health issue.
  • Understanding drug interactions is crucial for developing effective treatments.
  • Modafinil is a wakefulness-promoting agent with potential therapeutic applications.

Purpose of the Study:

  • To evaluate the pharmacokinetic and pharmacodynamic interactions between modafinil and intravenous cocaine.
  • To assess the safety and tolerability of combined modafinil and cocaine administration.

Main Methods:

  • Phase I clinical trial with 12 cocaine-dependent volunteers.
  • Randomized, blinded administration of saline, 20 mg IV cocaine, and 40 mg IV cocaine.
  • Open-label administration of modafinil at 0 mg, 400 mg, and 800 mg.

Related Experiment Videos

Main Results:

  • No significant hemodynamic interactions observed between modafinil and IV cocaine.
  • Modafinil significantly reduced subjective cocaine effects on Visual Analog Scale measures.
  • No significant alterations in laboratory values were reported.

Conclusions:

  • Modafinil appears to be safe and well-tolerated when co-administered with intravenous cocaine.
  • Modafinil may have potential as an adjunctive treatment for cocaine dependence by mitigating subjective effects.
  • Further outpatient trials are warranted to explore modafinil's efficacy in treating cocaine dependence.