Related Experiment Video

Updated: Jul 18, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

Prevention of bronchopulmonary dysplasia: finally, something that works

Virender K Rehan1

  • 1David Geffen School of Medicine at UCLA, Torrance, USA.

Indian Journal of Pediatrics
|November 28, 2006
PubMed

Insights

Bronchopulmonary dysplasia (BPD) in premature infants is linked to disrupted Parathyroid Hormone-related Protein (PTHrP) signaling. Stabilizing this pathway with PTHrP agonists may offer a novel therapeutic approach for BPD.

Area of Science:

  • Neonatal Medicine
  • Molecular Biology
  • Pulmonary Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant cause of infant mortality.
  • Current understanding of BPD pathogenesis is limited, lacking effective interventions.
  • Molecular mechanisms underlying BPD require further elucidation.

Purpose of the Study:

  • To investigate the molecular mechanisms of BPD pathogenesis.
  • To identify key signaling pathways involved in BPD.
  • To explore novel therapeutic targets for BPD.

Main Methods:

  • Basic biologic approach to study BPD pathophysiology.
  • Investigated the role of Parathyroid Hormone-related Protein (PTHrP) signaling.
  • Utilized exogenous PTHrP agonists in preclinical models.

Main Results:

  • Disruption of alveolar PTHrP signaling is central to BPD pathogenesis.
  • Stabilization of PTHrP signaling prevents and rescues molecular injuries.
  • Exogenous PTHrP agonists show potential in preventing/treating BPD.

Conclusions:

  • PTHrP signaling is a critical target for BPD intervention.
  • Exogenous PTHrP agonists represent a novel therapeutic strategy for BPD.
  • Further animal model testing is required before human trials.

More Related Videos

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Related Concept Videos

Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...