Related Experiment Video

Updated: Jul 18, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

Left ventricular remodeling of hypertrophic cardiomyopathy: longitudinal observation in rural community

Hiroaki Kitaoka1, Toru Kubo, Makoto Okawa

  • 1Cardiology Division, Department of Medicine and Geriatrics, Kochi Medical School, Nankoku-shi, Kochi, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|November 28, 2006
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) in rural Japan shows a benign course, but heart failure deaths increase after 10 years. Left ventricular remodeling is a key factor in long-term outcomes for HCM patients.

Area of Science:

  • Cardiology
  • Clinical Medicine
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Understanding the long-term clinical course of HCM is crucial for patient management.
  • Rural cohorts may present unique epidemiological characteristics.

Purpose of the Study:

  • To assess the long-term clinical course of hypertrophic cardiomyopathy (HCM) in a rural Japanese population.
  • To identify causes of mortality and long-term outcomes in this cohort.
  • To compare findings with existing data from developed regions.

Main Methods:

  • Retrospective analysis of 137 consecutive HCM patients in a rural Japanese cohort.
  • Long-term follow-up averaging 11.4 years.
  • Analysis of mortality causes, survival rates, and echocardiographic data.

Main Results:

  • Overall 5-, 10-, and 15-year survival rates were 91%, 88%, and 79%.
  • Sudden death predominated early, while heart failure deaths increased after 10 years.
  • End-stage HCM developed in 13% of patients, with 8 deaths from refractory heart failure, often linked to initial LV remodeling.

Conclusions:

  • HCM patients in this rural Japanese cohort exhibit a relatively benign long-term course, comparable to developed regions.
  • Heart failure mortality due to left ventricular (LV) remodeling becomes as significant as sudden death after 10 years of follow-up.
  • Early identification of LV remodeling indicators may aid in predicting severe outcomes.
Abstract

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...