Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outpatient hemithyroidectomy: A retrospective feasibility analysis.

European annals of otorhinolaryngology, head and neck diseases·2017
Same author

"De-novo" consultation: Evaluation of an outpatient's clinic dedicated to early diagnosis of parkinsonian syndromes.

Revue neurologique·2017
Same author

Clinical implications of neuropharmacogenetics.

Revue neurologique·2015
Same author

A phase II-III trial of olesoxime in subjects with amyotrophic lateral sclerosis.

European journal of neurology·2014
Same author

[Dementia: Where are the Lewy bodies?].

Revue neurologique·2013
Same author

[The new 2011 recommendations of the National Institute on Aging and the Alzheimer's Association on diagnostic guidelines for Alzheimer's disease: Preclinal stages, mild cognitive impairment, and dementia].

Revue neurologique·2012

Related Experiment Video

Updated: Jul 18, 2026

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
07:00

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

[Amyotrophic lateral sclerosis: cognitive and behavioral evaluation].

L Lacomblez1, A Piquard, M Vercelletto

  • 1Fédération des Maladies du Système Nerveux, Hôpital de la Salpêtrière, Paris.

Revue Neurologique
|November 28, 2006
PubMed
Summary

Cognitive impairment is common in amyotrophic lateral sclerosis (ALS) patients, often presenting as executive dysfunction. Neuropsychological testing and behavioral scales help assess daily life impacts.

More Related Videos

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)

Published on: February 21, 2011

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis
08:27

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Published on: September 2, 2021

Related Experiment Videos

Last Updated: Jul 18, 2026

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
07:00

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)

Published on: February 21, 2011

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis
08:27

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Published on: September 2, 2021

Area of Science:

  • Neurology
  • Neuropsychology

Background:

  • Cognitive impairment is increasingly recognized in nondemented patients with amyotrophic lateral sclerosis (ALS).
  • Frontotemporal dementia (FTD) is the most common dementia associated with ALS.
  • Executive dysfunction is a key feature, manifesting as neuropsychological deficits and behavioral changes.

Framework:

  • Psychometric evaluation focusing on executive functions is crucial.
  • Behavioral scales are used alongside cognitive tests.
  • This approach aims to comprehensively assess cognitive and behavioral changes.

Implementation:

  • Utilizing standardized neuropsychological tests to identify specific executive deficits.
  • Employing validated behavioral rating scales to capture functional impact.
  • Integrating cognitive and behavioral data for a holistic patient profile.

Implications:

  • Improved understanding of the cognitive profile in ALS.
  • Enhanced diagnostic accuracy for cognitive impairment in ALS.
  • Development of targeted interventions to manage cognitive and behavioral symptoms in ALS patients.