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Updated: Jul 18, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals
09:31

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

Oseltamivir: cutaneous and neurological adverse effects in children

    Prescrire International
    |November 30, 2006
    PubMed

    Insights

    Oseltamivir, an influenza antiviral, has limited effectiveness and potential serious adverse events in children, including neurological and behavioral issues. Weigh these risks against its modest benefits for influenza treatment and prevention.

    Area of Science:

    • Pharmacology
    • Pediatric Medicine
    • Infectious Diseases

    Background:

    • Oseltamivir is an antiviral medication used for influenza treatment.
    • Limited pediatric safety and efficacy data exist for oseltamivir.
    • Concerns have been raised regarding oseltamivir's neurological and behavioral side effects in children.

    Purpose of the Study:

    • To evaluate the safety and efficacy of oseltamivir in pediatric populations.
    • To review reported adverse events associated with oseltamivir use in children.
    • To assess the risk-benefit profile of oseltamivir for pediatric influenza management.

    Main Methods:

    • Review of adverse event reports from regulatory agencies (FDA, EMA).
    • Analysis of published literature on oseltamivir's pediatric use.
    • Examination of preclinical data from animal studies.

    Main Results:

    • Oseltamivir demonstrates modest efficacy in influenza prevention and treatment.
    • Serious adverse events reported include neurological (delirium, behavioral disorders, hallucinations, convulsions, confusion) and severe cutaneous reactions (Lyell syndrome).
    • Neurological toxicity observed in young rats, leading to warnings against use in infants under one year.

    Conclusions:

    • The benefits of oseltamivir in children appear limited, especially concerning its effectiveness on flu complications.
    • Serious adverse effects, including neuropsychiatric events and severe skin reactions, warrant careful consideration.
    • The risk-benefit balance of oseltamivir in pediatric populations requires cautious evaluation due to safety concerns and modest efficacy.

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