Related Experiment Video
Updated: Jul 18, 2026
09:01
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
[New systems for colonic drug targeting]
L Janovská1, D Vetchý, M Rabisková
1Veterinárí a farmaceutická univerzita Brno, Farmaceutická fakulta, Ustav technologie léků. l.janovska@seznam.cz
Summary
Colonic drug delivery systems offer targeted treatment for various diseases, including inflammatory bowel disease and circadian rhythm disorders. These systems leverage unique gastrointestinal tract features to enhance drug absorption and reduce systemic side effects.
Area of Science:
- Pharmacology
- Gastroenterology
- Drug Delivery Systems
Context:
- Colonic drug delivery is crucial for treating inflammatory bowel diseases (IBD), carcinomas, infections, and circadian rhythm-sensitive conditions like asthma and arthritis.
- The colon's unique environment, lacking digestive enzymes, facilitates the absorption of peptides, proteins, nucleotides, and vaccines into systemic circulation.
- Exploiting the gastrointestinal tract's pH gradient, transit time, pressure, and microflora enables targeted colonic drug delivery.
Purpose:
- To explore the therapeutic potential and mechanisms of colonic drug delivery systems.
- To highlight the advantages of direct colonic targeting for localized disease treatment.
- To reduce administered drug doses and minimize systemic adverse effects.
Summary:
- Colonic drug delivery systems are designed to release medications specifically in the colon.
- They utilize unique physiological characteristics of the gastrointestinal tract for controlled drug release and absorption.
- This targeted approach allows for effective treatment of colonic diseases and systemic conditions requiring delayed drug absorption.
Impact:
- Enables direct and effective treatment at the disease site, improving therapeutic outcomes.
- Potentially reduces the required drug dosage, thereby minimizing systemic toxicity and side effects.
- Offers a viable strategy for delivering sensitive biomolecules like peptides and vaccines systemically via the colon.
Related Concept Videos
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
01:26Oral Drug Delivery Systems: Continuous-Release Systems
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:19Modified-Release Drug Delivery Systems: Overview
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...