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Pain processing: paradoxes and predictions.

W J Martin1

  • 1Department of Pharmacology, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

Pain Practice : the Official Journal of World Institute of Pain
|November 30, 2006
PubMed
Summary
This summary is machine-generated.

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Despite advances in pain research, effective chronic pain treatments remain elusive. Current pain management relies on drugs like antidepressants and anticonvulsants, whose pain-relief mechanisms are often unclear and validated retrospectively in animal models.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Management

Background:

  • Significant progress in understanding pain physiology and pathophysiology over 25 years.
  • Development of animal models has aided in elucidating chronic pain mechanisms.
  • Lack of breakthrough treatments despite increased neurobiological understanding of pain.

Purpose of the Study:

  • To review current adjuvant and standard analgesics for difficult-to-manage pain.
  • To explore what can be learned from these drugs for novel pain medicine development.
  • To consider the predictive validity of animal models for clinical pain efficacy.

Main Methods:

  • Review of adjuvant analgesics (antidepressants, anticonvulsants, etc.) and standard analgesics.
  • Analysis of the mechanisms of action for current pain relief drugs.

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  • Evaluation of the use and predictive validity of animal models in pain research.

    • Main Results:

    • Chronic pain is managed by drugs with non-pain primary indications.
    • Mechanisms of action for adjuvant analgesics are often unknown or non-selective.
    • Efficacy of adjuvant analgesics in animal models is frequently validated post-clinical reporting.

    Conclusions:

    • Current pain management strategies have limitations.
    • The predictive validity of animal models for human pain requires further investigation.
    • Understanding existing analgesics may guide the development of more effective pain medications.