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Reproductive Cloning

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...

Reproductive Cloning

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...

Cloning of Dolly the Sheep

Cloning of Dolly the Sheep

The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual, the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter telomeres than other...

Introduction to Nuclear Reprogramming

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...

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Related Experiment Video

Updated: Jul 18, 2026

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning

Published on: December 19, 2025

Equine cloning.

Katrin Hinrichs¹

¹Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4466, USA. khinrichs@cvm.tamu.edu

The Veterinary Clinics of North America. Equine Practice

|November 30, 2006

Summary

Equine cloning is a growing clinical technique. Cloned foals may show some differences but will produce offspring reflecting the original donor, especially males lacking mitochondrial DNA.

Area of Science:

Animal science
Reproductive biology
Genetics

Background:

Equine cloning is an emerging clinical application.
Commercial availability and increasing efficiency are noted.
Cloned foals may exhibit phenotypic and behavioral variations from the donor.

Purpose of the Study:

To assess the viability and characteristics of cloned foals.
To understand factors influencing the production of viable cloned foals.
To compare similarities and differences between cloned foals and donor animals.

Main Methods:

Clinical application of equine cloning.
Monitoring of pregnancies and foal development.
Phenotypic and behavioral trait analysis.

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Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte

Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte

Published on: July 6, 2022

Functional Cloning Using a Xenopus Oocyte Expression System

Functional Cloning Using a Xenopus Oocyte Expression System

Published on: January 30, 2016

Related Experiment Videos

Last Updated: Jul 18, 2026

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning

A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning

Published on: December 19, 2025

Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte

Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte

Published on: July 6, 2022

Functional Cloning Using a Xenopus Oocyte Expression System

Functional Cloning Using a Xenopus Oocyte Expression System

Published on: January 30, 2016

Main Results:

Cloned foals are expected to produce offspring reflecting the original donor.
Male clones do not pass mitochondrial DNA to their progeny.
Further data from 2006 pregnancies will enhance understanding.

Conclusions:

Equine cloning is a viable clinical technique with potential for consistent genetic transmission.
Understanding variations in cloned offspring is crucial.
Ongoing research will refine the application and predictability of equine cloning.