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Updated: Jul 18, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
General principles and pharmacology of biologics in inflammatory bowel disease
Patricia L Kozuch1, Stephen B Hanauer
1Division of Gastroenterology, Department of Medicine, University of Chicago Hospitals, MC 4076, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Abstract:
The pharmacology of each biologic agent is important regarding the dose required to achieve benefits, duration of therapeutic effect, and the induction of immunogenicity. Comprehension of the individual pharmacology, pharmacodynamics, and pharmacokinetics, in addition to the impact of concomitant immunomodulation on immunogenicity allows optimization of each biologic agent in the appropriate inductive or maintenance setting of IBD.
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