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Patch Angioplasty in the Rat Aorta or Inferior Vena Cava
Published on: February 27, 2017
Valved patch for ventricular septal defect with pulmonary arterial hypertension
Abbas Afrasiabi1, Mahmoud Samadi, Hossein Montazergaem
1Cardiovascular Research Center, Madani Heart Hospital, University of Medical Sciences, Tabriz, Iran. aafrasa@yahoo.com
Asian Cardiovascular & Thoracic Annals
|November 30, 2006
Summary
A novel valved patch technique for large ventricular septal defects significantly reduced pulmonary vascular resistance in pediatric patients. This surgical approach shows promise for managing severe pulmonary arterial hypertension.
Area of Science:
- Cardiovascular Surgery
- Pediatric Cardiology
- Pulmonary Hypertension
Background:
- Large ventricular septal defects (VSD) can lead to elevated pulmonary vascular resistance (PVR).
- Severe pulmonary arterial hypertension (PAH) presents significant surgical challenges and high mortality rates.
Purpose of the Study:
- To evaluate the efficacy of a novel valved patch technique in patients with large VSD and severe PAH.
- To assess the impact of this technique on PVR and clinical outcomes.
Main Methods:
- Surgical closure of large VSDs using a Gore-Tex patch with a pericardial valve.
- Placement of the pericardial aspect towards the left ventricle to facilitate right-to-left shunting.
- Echocardiography and PVR measurements for pre- and post-operative assessment.
Main Results:
- Two of 16 patients (12.5%) died early postoperatively due to pulmonary hypertensive crises.
- PVR decreased significantly in most patients over a 3-year follow-up.
- One patient developed increased PVR with a right-to-left shunt and cyanosis.
Conclusions:
- The valved patch technique appears promising for reducing morbidity and mortality in severe PAH associated with large VSDs.
- This approach may offer a viable surgical option for complex congenital heart disease with pulmonary hypertension.
