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Molecular scanning of the gene for programmed cell death-1 (PDCD-1) as a candidate for type 1 diabetes susceptibility

Yoshihisa Hiromine1, Hiroshi Ikegami, Tomomi Fujisawa

  • 1Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.

Annals of the New York Academy of Sciences
|November 30, 2006
PubMed

Insights

Researchers investigated the PDCD1 gene

Area of Science:

  • Immunology
  • Genetics

Background:

  • Autoimmune type 1 diabetes involves multiple genes.
  • Programmed cell death-1 (PDCD-1) regulates peripheral tolerance and may influence type 1 diabetes development.
  • The human PDCD1 gene is a candidate for type 1 diabetes susceptibility.

Purpose of the Study:

  • To sequence the human PDCD1 gene in Japanese subjects.
  • To identify sequence variants within the PDCD1 gene.
  • To investigate the association of PDCD1 polymorphisms with type 1 diabetes susceptibility.

Main Methods:

  • Sequencing of all 5 exons and exon-intron junctions of the PDCD1 gene.
  • Analysis of sequence variants in Japanese individuals.
  • Preliminary association study with type 1 diabetes.

Main Results:

  • Ten sequence variants were identified in the PDCD1 gene.
  • Preliminary data indicated no association between these PDCD1 polymorphisms and type 1 diabetes.
  • The identified variants provide a resource for future research.

Conclusions:

  • The studied PDCD1 sequence variants do not appear to be associated with type 1 diabetes in the Japanese population.
  • Further research is needed to fully elucidate the role of PDCD1 in type 1 diabetes pathogenesis.
  • The identified variants are valuable for future genetic studies of type 1 diabetes.

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